FITC标记的整合素和生长因子样蛋白1抗体
产品名称： FITC标记的整合素和生长因子样蛋白1抗体
英文名称： Anti-LIMS1/FITC
产品编号： HZ-5951R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-LIMS1/FITC Conjugated antibody
FITC标记的整合素和生长因子样蛋白1抗体
| 英文名称 | Anti-LIMS1/FITC |
| 中文名称 | FITC标记的整合素和生长因子样蛋白1抗体 |
| 别 名 | Lims1l; LIM and senescent cell antigen like domains 1; Particularly interesting new Cys His protein 1; PINCH; PINCH1; Renal carcinoma antigen NY REN 48; LIMS1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LIMS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. Subunit: Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors. Subcellular Location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in most tissues except in the brain. Similarity: Contains 5 LIM zinc-binding domains. Database links: Entrez Gene: 3987 Human Entrez Gene: 110829 Mouse Entrez Gene: 499443 Rat Omim: 602567 Human SwissProt: P48059 Human SwissProt: Q99JW4 Mouse Unigene: 597715 Human Unigene: 613268 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
整合素和生长因子信号的效应，偶联表面受体与下游信号分子参与调节细胞存活、细胞增殖和细胞分化。复杂ILK箍缩的粘着蛋白部分。该复合物被认为是整合素和生长因子信号通路的融合点之一。