FITC标记的G蛋白γ5/Gγ5 抗体
产品名称： FITC标记的G蛋白γ5/Gγ5 抗体
英文名称： Anti-GNG5/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GNG5/FITC Conjugated antibody
FITC标记的G蛋白γ5/Gγ5 抗体
| 英文名称 | Anti-GNG5/FITC |
| 中文名称 | FITC标记的G蛋白γ5/Gγ5 抗体 |
| 别 名 | FLJ92393; GBG5_HUMAN; Gng5; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; OTTHUMP00000011474; OTTHUMP00000011565. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 7kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GNG5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (i.e. a photon, pheromone, odorant, hormone or neurotransmitter), while the effectors (e.g. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alhfa, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Evidence, however, has established an important regulatory role for the beta gamma subunits. It is becoming increasingly clear that different G protein complexes expressed in different tissues carry structurally distinct members of the gamma as well as the alhfa and beta subunits, and that preferential associations between members of subunit families increase G protein functional diversity. Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Subcellular Location: Cell membrane. Similarity: Belongs to the G protein gamma family. Database links: Entrez Gene: 2787 Human Entrez Gene: 14707 Mouse Entrez Gene: 79218 Rat Omim: 600874 Human SwissProt: P63218 Human SwissProt: Q80SZ7 Mouse SwissProt: P63219 Rat Unigene: 645427 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
异三聚体G蛋白的功能是将信息从细胞表面受体传递到细胞内效应物。每一种非常广泛的受体特异性地检测细胞外刺激(即光子、信息素、气味剂、或神经递质)，而起产生一种或多种细胞内信使作用的效应物(例如腺苷环化酶)数量较少。在哺乳动物中，G蛋白ALHFA、β和γ多肽分别由至少16, 4个和7个基因编码。由于G蛋白结合并水解GTP，并且最明显地调节所研究的最佳效应子的活性，因此人们对G蛋白的兴趣主要集中在它们的a亚基。然而，证据已经建立了β-γ亚基的重要调节作用。越来越清楚的是，在不同组织中表达的不同G蛋白复合物携带结构上不同的γ亚基以及α亚基和β亚基，并且亚基家族成员之间的优先关联增加了G蛋白功能的多样性。