FITC标记的G蛋白偶联受体126抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的G蛋白偶联受体126抗体

FITC标记的G蛋白偶联受体126抗体

商家询价

产品名称： FITC标记的G蛋白偶联受体126抗体

英文名称： Anti-GPR126/FITC

产品编号： HZ-12027R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-GPR126/FITC Conjugated antibody

FITC标记的G蛋白偶联受体126抗体

 

英文名称 Anti-GPR126/FITC
中文名称 FITC标记的G蛋白偶联受体126抗体
别    名 APG1; Developmentally regulated G-protein-coupled receptor; dj287g14.2; DREG; G-protein coupled receptor 126; GP126_HUMAN; GPR126; HBV PreS1-transactivated protein 2; OTTHUMP00000017320; OTTHUMP00000237093; OTTHUMP00000237094; OTTHUMP00000237115; Probable G-protein coupled receptor 126 [Precursor]; Probable G-protein coupled receptor 126; PS1TP2; Vascular inducible G protein-coupled receptor; VIGR; GPCR GPR126.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  细胞膜受体  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G-protein coupled receptor 126
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR126 (G protein-coupled receptor 126), also known as APG1, DREG, VIGR or PS1TP2, is a 1,221 amino acid multi-pass membrane protein that contains one pentaxin domain, one GPS domain and one CUB domain. Existing as three alternatively spliced isoforms, GPR126 functions as an orphan G protein-coupled receptor that, when subject to genetic variation, may influence stature and adult height. 

Function:
Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.

Subcellular Location:
Cell membrane. Detected on the cell surface of activated but not resting umbilical vein.

Tissue Specificity:
Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.

Post-translational modifications:
Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. 

DISEASE:
Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 CUB domain.
Contains 1 GPS domain.
Contains 1 pentaxin domain.

Database links:
UniProtKB/Swiss-Prot: Q86SQ4.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

G蛋白偶联受体(GPR)又称七种跨膜受体、七肽受体或七肽甲基转移酶(7TM)受体，由在许多不同的刺激-反应途径中起作用的蛋白超家族组成。G蛋白偶联受体将细胞外信号翻译成细胞内信号（G蛋白激活），并对多种信号分子作出反应，如激素和神经递质。GPR126(G蛋白偶联受体126)又称APG1、DREG、VIGR或PS1TP2，是一种1221个氨基酸的多程膜蛋白，含有一个五肽结构域、一个GPS结构域和一个CUB结构域。GPR126作为三种可选择的剪接异构体存在，其作为孤儿G蛋白偶联受体的功能，当受到遗传变异时，可能影响身高和成人身高。